CrossLinked HA
Hydrogel forming crosslinked hyaluronic acid powder
Working as a delivery system and enabling gradual release of active ingredients into the skin. The final product is a water-soluble powder with no preservatives nor stabilizers needed and has better solubility in comparison to other gelled crosslinked HA.
- more stable than HA
- immediate reduction of wrinkles
- higher hydrating capabilities than HMW HA
- reservoir of water and active ingredients enabling
their gradual release - prepared by crosslinking of an HA-derivative
in the presence of standard HA
Increase of immediate
hydration after 1 hour
Higher hydration
after 4 hours
More hydration than
standard MW HA
DAY CREAMS
0.05 — 0.10%
EYE CREAMS
0.05 — 0.10%NIGHT CREAMS
0.05 — 0.15%
SERUMS
0.05 — 0.20%
LOTIONS
0.05 — 0.10%
MASKS
0.05 — 0.10%
Mechanism of action
Hydrogel. Water reservoir and reservoir of various active ingredients inside its pores. Enables gradual release of actives into the skin, it prolongs their bioavailability. Higher resistance against hyaluronidases.
INCI
Sodium Hyaluronate ImineCross-polymer (proposal)
Source
CrossLinkedHA is produced by chemical modification. Hyaluronic Acid-aldehyde is crosslinked with POA (O,O´- 1,3 propanediylbishydroxylamine dihydrochloride) in the presence of standard HA.
Compatibility processing
Sensitive to heat; heating to 60°C at pH about 7.0 for 60 min. can lead to the degradation of crosslinked network. Sensitive to extreme pH values (less than 4 or more than 10) lead to the decomposition of the polymer and this process is accelerated by heating.Incompatible with strong oxidation or reduction agents and polymeric cationic substances (e.g. Polyquarternium–4, Polyquarternium–10, etc.). Addition of multivalent metals (e.g. Fe3+, Zn2+, Mg2+) can significantly modify quality of the crosslinked network.
In-vivo study conditions
Double-blind, placebo-controlled, split-face study; Cream with 0.01% CrossLinkedHA Placebo: the same cream containing 0.01% standard molecular weight HA 4 hours, 8 volunteers, measured by corneometer and 3D camera Primos Lite.
CrossLinked HA products bring
a broad range of advantages:
- Forming a hydrogel in the presence of water.
- Water reservoir and reservoir of various active ingredients inside its pores and enables their gradual release into the skin, it prolongs their bioavailability in the skin.
- Decreasing the irritation risk caused by some active ingredients.
- Higher resistance against hyaluronidases (enzymes present in the skin which degrade HA).
- Better results in comparison with commercially available crosslinked HA with divinylsulfone (HA — DVS).
